I hunt exclusively with copper bullets, Barnes being a favorite. Penetration is hardly ever a problem, but good bullet placement on a broadside shot, taking arteries above or the heart itself and both lungs, is a deadly shot. Avoid headshots, although a neck shot just below the head works well. On the shoulder is prescribed.
Usually there is less meat damage and snotty blood is absent.
I have had 1 MOA groups or less - ample precision for hunting out to 400m. The 130gr bullet is prescribed for 308 to get enough speed to ensure good expansion. I have shot an eland with 150gr TSX in my 30-06. Nearly full length penetration at 100m.